· ChenLab

Selected Publications

Chen S, He LM, Huang AJY, Boehringer R, Robert V, Wintzer ME, Polygalov D, Weitemier AZ, Tao YQ, Gu MX, Namiki K, Hama H, Therreau L, Hioki H, Miyawaki A, Piskorowski RA, McHugh TJ. A hypothalamic novelty signal modulates hippocampal memory. Nature. 586:270–274 (2020).
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Trends in Neurosciences Spotlight: Parallel pathways for mnemonic processing

Chen S. Optical modulation goes deep in the brain. Science. 365:456–457 (2019).

Zeng X*, Chen S*, Weitemier A, Han S, Blasiak A, Prasad A, Zheng K, Yi Z, Luo B, Yang IH, Thakor N, Chai C, Lim KL, McHugh TJ, All AH, Liu X. Visualization of intra-neuronal motor protein transport through upconversion nanoscopy. Angewandte Chemie International Edition. 58:9262–9268 (2019).

Middleton SJ, Kneller EM, Chen S, Ogiwara I, Montal M, Yamakawa K, McHugh TJ. Altered hippocampal replay is associated with memory impairment in mice heterozygous for the Scn2a gene. Nature Neuroscience. 21:996 1003 (2018).

Chen S, Itoh Y, Masuda T, Shimizu S, Zhao J, Ma J, Nakamura S, Okuro K, Noguchi H, Uosaki K, Aida T. Subnanoscale hydrophobic modulation of salt bridges in aqueous media. Science. 348:555–559 (2015).

All Publications

Chen S, Lam N, Li Z, Wang D, Liu P, Berbano V, Xie Y, Nguyen T, Xu Y, Yang J, Ha K, Semana L, Dias R, Masurkar AV, Wisniewski T. Acute Aβ12-28P administration targeting apoE/Aβ interaction rescues synaptic function and cognitive decline in advanced-stage Alzheimer’s disease. Alzheimer’s Association International Conference. (2024).

Mao H, Tang J, Day GS, Peng Y, Wang H, Xiao X, Yang Y, Jiang Y, Chen S, Halat DM, Lund A, Lv X, Zhang W, Yang C, Lin Z, Zhou HC, Pines A, Cui Y, Reimer JA. A scalable solid-state nanoporous network with atomic-level interaction design for carbon dioxide capture. Science Advances. 8:eabo6849 (2022).

Chen S, McHugh TJ. Further-reaching optogenetics. Nature Biomedical Engineering. 4:1028-1029 (2020).

Chen S. Near-infrared deep brain stimulation in living mice Methods in Molecular Biology. 2173:71-82 (2020).

Wu J, Liang Y, Chen S, Hsu CL, Chavarha M, Evans SW, Shi D, Lin MZ, Tsia KK, Ji N. Kilohertz Two-photon fluorescence microscopy imaging of neural activity in vivo. Nature Methods. 17:287–290 (2020).

Mao H, Tang J, Xu J, Peng Y, Chen J, Wu B, Jiang Y, Hou K, Chen S, Wang J, Lee HR, Halat DM, Zhang B, Chen W, Plantz AZ, Lu Z, Cui Y, Reimer JA. Revealing molecular mechanisms in hierarchical nanoporous carbon via nuclear magnetic resonance. Matter. 3: 2093–2107 (2020).

Fu T, Xing H, Silver ES, Itoh Y, Chen S, Masuda T, Uosaki K, Huang F, Aida T. Anomalously slow conformational change dynamics of polar groups anchored to hydrophobic surfaces in aqueous media. Chemistry – An Asian Journal. 15:3321–3325 (2020).

Chen S. Optical modulation goes deep in the brain. Science. 365:456–457 (2019).

Chen S*, Weitemier AZ, Zeng X, He LM, Wang XY, Tao YQ, Huang AJY, Hashimotodani Y, Kano M, Iwasaki H, Parajuli KL, Okabe S, Loong Teh DB, All AH, Tsutsui-Kimura I, Tanaka KF, Liu X, McHugh TJ. Near-infrared deep brain stimulation via upconversion nanoparticle mediated optogenetics. Science. 359:679–684 (2018).